Free shipping on all orders over $ 500

JTE 013

Cat. No. M2787

All AbMole products are for research use only, cannot be used for human consumption.

JTE 013 Structure
Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 110 In stock
25mg USD 240 In stock
50mg USD 440 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

Customer Product Validations & Biological Datas
Source J Neurophysiol (2012). Figure 1. JTE 013
Method RT-PCR
Cell Lines sensory neurons
Concentrations 100 nM
Incubation Time 15-min
Results The number of APs at each time point was then normalized to the respective control values, and this analysis demonstrated that JTE-013 produced a rapid and significant increase in excitability in 70% of the sensory neurons compared with their control values
Chemical Information
Molecular Weight 408.29
Formula C17H19Cl2N7O
CAS Number 383150-41-2
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Melissa R Pitman, et al. The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

[2] Qiumin Xu, et al. JTE-013 Alleviates Inflammatory Injury and Endothelial Dysfunction Induced by Sepsis In Vivo and In Vitro

[3] Meng Pang, et al. Inhibitory Effect of S1PR2 Antagonist JTE-013 on Proliferation of Chronic Myeloid Leukemia Cells

[4] Jisoo Kang, et al. Topical Application of S1P 2 Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

[5] K Liu, et al. JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis

[6] Mei-Hong Li, et al. J Pharmacol Exp Ther . Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma

[7] Jen-Fu Lee, et al. Am J Physiol Heart Circ Physiol . Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature

Related S1P Receptor Products
FTY720 hydrochloride

Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells.
BAF312

BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.
SEW2871

SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling.
CYM-5442

CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 can easily penetrate the central nervous system (CNS).
KRP-203 hydrochloride

Mocravimod (KRP-203) hydrochloride is a potent, orally active sphingosine receptor S1P1 and S1P4 agonist with EC50s of 1 nM and 10 nM, respectively, and may be used in studies related to ulcerative colitis (UC).
  Catalog
Abmole Inhibitor Catalog




Keywords: JTE 013 supplier, S1P Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.