Free shipping on all orders over $ 500

JP1302 

Cat. No. M30631

All AbMole products are for research use only, cannot be used for human consumption.

JP1302  Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

JP1302 is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 shows antidepressant and antipsychotic-like effects. JP1302 can be used for neuropsychiatric disorders and renal dysfunction research.

Chemical Information
Molecular Weight 368.47
Formula C24H24N4
CAS Number 80259-18-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Dylan C Mitchell, et al. Nat Biotechnol. A proteome-wide atlas of drug mechanism of action

[2] Xiaoyu Chen, et al. Cell Rep. Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor

[3] Hidenobu Tsutsui, et al. Eur J Pharmacol. Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats

[4] Joanna Raczak-Gutknecht, et al. Dose Response. Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?

[5] Michiko Nakamura, et al. J Neurochem. α(2A) adrenoceptor-mediated presynaptic inhibition of GABAergic transmission in rat tuberomammillary nucleus neurons

Related Adrenergic Receptor Products
Tamsulosin hydrochloride

Tamsulosin is a new, highly selective α1A-adrenoceptor antagonist.

Mirabegron

Mirabegron (YM178) is a potent and selective β(3)-adrenoceptor agonist with EC50 of 22.4 nM.

Detomidine hydrochloride

Detomidine hydrochloride is a nonnarcotic, synthetic alpha-2 adrenoreceptor agonist.

(R)-(+)-Atenolol

(R)-(+)-Atenolol binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists.

Reboxetine mesylate

Reboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively).

  Catalog
Abmole Inhibitor Catalog




Keywords: JP1302  supplier, Adrenergic Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.