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JNJ4796 

Cat. No. M29409

All AbMole products are for research use only, cannot be used for human consumption.

JNJ4796  Structure

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Quality Control & Documentation
Biological Activity

JNJ4796 is an oral active fusion inhibitor of influenza virus, neutralizing influenza A group 1 viruses by inhibiting hemagglutinin (HA)-mediated fusion. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs).

Chemical Information
Molecular Weight 537.57
Formula C28H27N9O3
CAS Number 2241664-16-2
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wenhao Wu, et al. Eur J Med Chem. Optimization and SAR research at the benzoxazole and tetrazole rings of JNJ4796 as new anti-influenza A virus agents, part 2

[2] Lucía Díaz, et al. RSC Adv. Monte Carlo simulations using PELE to identify a protein-protein inhibitor binding site and pose

[3] Aoyu Wang, et al. Eur J Med Chem. Optimization and SAR research at the piperazine and phenyl rings of JNJ4796 as new anti-influenza A virus agents, part 1

[4] Yao Yao, et al. Proc Natl Acad Sci U S A. An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen

[5] Maria J P van Dongen, et al. Science. A small-molecule fusion inhibitor of influenza virus is orally active in mice

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Keywords: JNJ4796  supplier, Anti-infection, inhibitors, activators

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