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JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.
| Molecular Weight | 316.78 |
| Formula | C17H17ClN2O2 |
| CAS Number | 1802326-66-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 31.68 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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