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JNJ 303

Cat. No. M14256

All AbMole products are for research use only, cannot be used for human consumption.

JNJ 303 Structure

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Quality Control & Documentation
Biological Activity

JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).

Chemical Information
Molecular Weight 440.98
CAS Number 878489-28-2
Solubility (25°C) DMSO 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rachael L DiSantostefano, et al. Using Societal Values to Inform Public Health Policy During the COVID-19 Pandemic: The Role of Health Preference Research

[2] Edward Phillips, et al. Safety and effectiveness of REALIZE adjustable gastric band: 5-year prospective study

[3] Susann Bjrk, et al. Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes

[4] C Kang, et al. β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents I Ks and I Kr in the human ventricle

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Keywords: JNJ 303 supplier, Potassium Channel, inhibitors, activators

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