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JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na+ channels and N-type Ca2+ channels, and is effective as a K+ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC50=35 μM) and CA-I (18 μM).
| Molecular Weight | 278.71 |
| Formula | C9H11ClN2O4S |
| CAS Number | 871824-55-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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