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JNJ-26076713 

Cat. No. M30455

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JNJ-26076713  Structure

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Quality Control & Documentation
Biological Activity

JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC50 values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization.

Chemical Information
Molecular Weight 490.64
Formula C29H38N4O3
CAS Number 669076-03-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Ashay D Bhatwadekar, et al. Expert Opin Investig Drugs. Anti-integrin therapy for retinovascular diseases

[2] William A Kinney, et al. J Org Chem. Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies

[3] Rosemary J Santulli, et al. J Pharmacol Exp Ther. Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats

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  Catalog
Abmole Inhibitor Catalog




Keywords: JNJ-26076713  supplier, Integrin, inhibitors, activators

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