All AbMole products are for research use only, cannot be used for human consumption.
JMV 449 acetate is a potent neurotensin receptor agonist (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.
| Molecular Weight | 807.03 |
| Formula | C40H70N8O9 |
| CAS Number | 139026-66-7 (free base) |
| Solubility (25°C) | Water 90 mg/mL |
| Storage | -20°C, sealed |
| Related Neurotensin Receptor Products |
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| AF38469
AF38469 |
| Meclinertant
Meclinertant (SR 48692) is an effective, selective, non-peptide and oral antagonist of active neurotensin receptor (NTS1). Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization in human colon cancer cells, with a pA2 value of 8.13. Meclinertant has anti-anxiety, anti-addiction and memory disorder effects. |
| SBI-553
SBI-553 is a potent and effective, brain-penetrant and allosteric modulator of NTR1 with EC50 of 0.34 μM. |
| Neurotensin
Neurotensin is a gut tridecapeptide with many central and peripheral functions, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors(NTR). |
| AF40431
AF40431 is the first reported small molecule ligand of sortilin with IC50 of 4.4 µM and Kd of 0.7 µM. AF40431 binds to the neurotensin binding site of sortilin. |
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Products are for research use only. Not for human use. We do not sell to patients.
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