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JHU37160 

Cat. No. M29552

All AbMole products are for research use only, cannot be used for human consumption.

JHU37160  Structure
Size Price Availability Quantity
5mg USD 35 In stock
10mg USD 50 In stock
25mg USD 95 In stock
50mg USD 150 In stock
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Biological Activity

JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.

Chemical Information
Molecular Weight 358.84
Formula C19H20ClFN4
CAS Number 2369979-68-8
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jacqueline Van Savage, et al. Behav Brain Res. High dose administration of DREADD agonist JHU37160 produces increases in anxiety-like behavior in male rats

[2] Jana Desloovere, et al. Neurotherapeutics. Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model

[3] Jordi Bonaventura, et al. Nat Commun. High-potency ligands for DREADD imaging and activation in rodents and monkeys

[4] Michele L Singer, et al. J Neurophysiol. Chemogenetic activation of hypoglossal motoneurons in a mouse model of Pompe disease

[5] Kate A Lawson, et al. bioRxiv. A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition

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Keywords: JHU37160  supplier, AChR/AChE, inhibitors, activators

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