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Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments.
In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM).
In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.
| Molecular Weight | 709.67 |
| Formula | C36H45BrN4O6 |
| CAS Number | 102396-24-7 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 4 mg/mL |
| Storage | -20°C, dry, sealed |
[5] A Holzinger. Jasplakinolide. An actin-specific reagent that promotes actin polymerization
| Related Actin-Related Protein Products |
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| CK-636
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. |
| CK 666
Ck-666 is a cell-permeable inhibitor (IC50=12 μM) of the Arp2/3 complex, which binds to the Arp2/3 complex and stabilizes the inactive state of the complex, preventing the movement of Arp2 and Arp3 subunits into the active filamentous conformation. |
| CK 869
Ck-869 is an inhibitor of the actin associated protein 2/3 complex (ARP2/3) with an IC50 value of 7 μM. |
| Latrunculin A
Latrunculin A (Latrunculia magnifica) is A toxin obtained from the Red Sea sponge Latrunculia magnifica that binds to actin monocytes and inhibits actin aggregation, inhibiting atP-actin, ADP-pi-actin, Kd values of ADP-actin and G-actin were 0.1, 0.4, 4.7 μM and 0.19 μM, respectively. |
| SMIFH2
SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation. |
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