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Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells.
| Molecular Weight | 2221.42 |
| Formula | C95H128F3N25O28S3 |
| CAS Number | 219127-21-6 (free base) |
| Solubility (25°C) | Water 50 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Notch Products |
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| FLI-06
FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |
| LY900009
LY900009 is a potent, first-in-class Notch inhibitor with IC50 of 0.27 nM. |
| Tangeretin
Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. |
| IMR-1
IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 μM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity. |
| NVS-ZP7-4
NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. |
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