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IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
Int Immunopharmacol. 2025 Nov 20; .
Ganetespib as an inhibitor of heat shock protein 90 alleviates pulmonary fibrosis by inhibiting the Wnt/beta-catenin signaling pathway
IWR-1-endo purchased from AbMole
Aquaculture Reports. 2023 Dec;101784.
Squalene activates Wnt/β-Catenin signaling pathway to mediate NF-κB pathway to regulate inflammatory response and disease resistance in hybrid grouper
IWR-1-endo purchased from AbMole
Adv Sci (Weinh). 2022 Nov 14;10(1):e2205451.
Podocalyxin‐Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway
IWR-1-endo purchased from AbMole
Patent. WO2020139914A1 2020 Jul 02.
Patent. WO2020139914A1
IWR-1-endo purchased from AbMole
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Source | Sci Rep (2017). Figure 3. IWR-1-endo |
| Method | qPCR | |
| Cell Lines | EMSC osteogenic | |
| Concentrations | 10 μM | |
| Incubation Time | 24 h | |
| Results | To further study whether the Wnt/β-catenin pathway is involved in regulating EMSC osteogenic differentiation, we treated EMSCs with the Wnt signalling inhibitor IWR-1-endo and the Wnt signalling agonist SKL2001 before osteogenic induction. |
| Cell Experiment | |
|---|---|
| Cell lines | Human osteosarcoma cell lines 143b |
| Preparation method | For therapy, necrosulfonamide (NSA) was applied in different concentrations (1, 5 and 10 μM) 1 h after SM exposure. The medium was not removed during the experiment procedure. DMSO served as solvent and was added to the THP-medium for the sham-treated wells in equivalent amounts. After NSA therapy, cells were incubated for another 24 h under before mentioned conditions. |
| Concentrations | 1, 5 and 10 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | CD1 nude mice |
| Formulation | DMSO |
| Dosages | 30 mg/kg |
| Administration | Intraperitoneal administration |
| Molecular Weight | 409.44 |
| Formula | C25H19N3O3 |
| CAS Number | 1127442-82-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Wnt/beta-catenin Products |
|---|
| XAV939
XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| ICG-001
ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. ICG-001 specifically binds to cyclic AMP response element-binding protein with an IC50 of 3 μM. |
| IWP-2
IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| IWP-L6
IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM. |
| LGK-974
LGK-974 (WNT-974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM. |
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