All AbMole products are for research use only, cannot be used for human consumption.
IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.
Nucleic Acids Res. 2024 Feb;gkae057.
Selection-free precise gene repair using high-capacity adenovector delivery of advanced prime editing systems rescues dystrophin synthesis in DMD muscle cells
IWP-L6 purchased from AbMole
bioRxiv. 2024 Jun 24.
Organs-on-chip: towards therapies for cardiovascular disease using human stem cells
IWP-L6 purchased from AbMole
Nucleic Acids Res. 2022 Jul 22;50(13):7761-7782.
Large-scale genome editing based on high-capacity adenovectors and CRISPR-Cas9 nucleases rescues full-length dystrophin synthesis in DMD muscle cells
IWP-L6 purchased from AbMole
Cell Reports Methods. 2022 Oct 24.
STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells
IWP-L6 purchased from AbMole
BioRxiv. 2021 Dec 08;471715.
STRAIGHT-IN: A platform for high-throughput targeting of large DNA payloads into human pluripotent stem cells
IWP-L6 purchased from AbMole
Stem Cell Res. 2020 Mar;43:101698.
Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties.
IWP-L6 purchased from AbMole
| Molecular Weight | 472.58 |
| Formula | C25H20N4O2S2 |
| CAS Number | 1427782-89-5 |
| Solubility (25°C) | DMSO ≥ 15 mg/mL (with 50ºC water bath) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Wnt/beta-catenin Products |
|---|
| XAV939
XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively. |
| ICG-001
ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription. ICG-001 specifically binds to cyclic AMP response element-binding protein with an IC50 of 3 μM. |
| IWP-2
IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM. |
| IWR-1-endo
IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
| LGK-974
LGK-974 (WNT-974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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