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ITK degrader 1 is a highly selective degrader of interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice).
| Molecular Weight | 943.02 |
| Formula | C48H57F3N10O7 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Michael C McGee et al. Adv Exp Med Biol. TCR/ITK Signaling in Type 1 Regulatory T cells
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Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease. Soquelitinib increases tumor infiltration of normal CD8+ cells that possess enhanced T effector function. |
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