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ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively.
ITI-214 showed good efficacy in vivo, it is found to significantly enhance memory performance in the test with a minimum effective dose of 3 mg/kg.
| Molecular Weight | 605.56 |
| Formula | C29H29FN7O5P |
| CAS Number | 1642303-38-5 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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