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ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM. ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.
In vivo, ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.
Cell Death Dis. 2023 Feb 8;14(2):92.
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury
ITE purchased from AbMole
| Molecular Weight | 286.31 |
| Formula | C14H10N2O3S |
| CAS Number | 448906-42-1 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Pang LP, et al. Exp Lung Res. ITE inhibits growth of human pulmonary artery endothelial cells.
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