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Isorhamnetin inhibited atherosclerotic plaque development in ApoE-/- mice by PI3K/AKT activation and HO-1 induction.Isorhamnetin inhibited the viability, potentiated the apoptotic effects of capecitabine, abrogated NF-κB activation, and suppressed the expression of various NF-κB regulated gene products in tumor cells.Isorhamnetin further reduced NF-κB activation and the expression of various proliferative and oncogenic biomarkers in tumor tissues.Isorhamnetin can significantly enhance the anti-tumor effects of capecitabine through the negative regulation of NF-κB regulated oncogenic genes.Iso markedly inhibited the growth of A549 cells with induction of apoptotic changes.Its mechanisms of action may involve apoptosis of cells induced by down-regulation of oncogenes and up-regulation of apoptotic genes.
| Molecular Weight | 316.26 |
| Formula | C16H12O7 |
| CAS Number | 480-19-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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