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Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercitrin is a rare, natural ingredient with several biological activities that is a key precursor for the synthesis of enzymatically modified isoquercitrin (EMIQ). Isoquercitrin attenuated FFA induced lipid overload and ROS within hepatocytes. Further, Isoquercitrin reversed FFA induced increase in intracellular TG SOD and MDA. It was shown that antioxidative activity of Isoquercitrin correlates with its lipid lowering potentials. Isoquercitrin reversed major proinflammatory cytokines and oxidative stress in FFA/LPS induced coculture model.Isoquercitrin inhibits human pancreatic cancer progression in vivo and in vitro and that its molecular mechanism may be closely related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. Isoquercitrin exerts its fungicidal effect by disturbing the membrane of cells.
| Molecular Weight | 464.38 |
| Formula | C21H20O12 |
| CAS Number | 482-35-9 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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