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Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions.
| CAS Number | 1461640-62-9 |
| Storage | Store at ≤ -70°C for 2 years. Avoid multiple freeze-thaws. |
[2] James E Frampton. Target Oncol. Isatuximab: A Review of Its Use in Multiple Myeloma
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