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Irsogladine

Cat. No. M3259

All AbMole products are for research use only, cannot be used for human consumption.

Irsogladine Structure
Synonym:

Dicloguamine

Size Price Availability Quantity
500mg USD 50 In stock
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Quality Control & Documentation
Biological Activity

Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. It is a potent inhibitor of angiogenesis and protects MNNG-induced gastric carcinogenesis in rats.

Chemical Information
Molecular Weight 256.09
Formula C9H7Cl2N5
CAS Number 57381-26-7
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Keiji Yokoyama, et al. Irsogladine maleate alters expression of a tight junction protein in portal hypertensive gastropathy

[2] Seong Chun Kwon, et al. Gastroprotective effects of irsogladine maleate on ethanol/hydrochloric acid induced gastric ulcers in mice

[3] Ki-Nam Shim, et al. The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis

[4] Wakana Onuma, et al. Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice

[5] Michiyo Akagi, et al. Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract

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Keywords: Irsogladine, Dicloguamine supplier, PDE, inhibitors, activators

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