All AbMole products are for research use only, cannot be used for human consumption.
Ionomycin causes a rapid rise in cytosolic Ca2+ that is due to both a release of cytosolic Ca2+ stores and Ca2+ influx. Ionomycin also activates (2 microM) and primes (20-200 nM) the PMN oxidase. Ionomycin is shown to be an effective ionophore for Ca2+ in rat liver mitochondria. DNA and protein analysis in Ionomycin (SQ23377)-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Three hours after addition of ionomycin, the percentage of early apoptotic cells approximately doubles. Necrosis could be detected in ~1-5% of the Ionomycin (SQ23377) treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake.
Nat Commun. 2024 Oct 23;15(1):9114.
A splicing isoform of PD-1 promotes tumor progression as a potential immune checkpoint
Ionomycin purchased from AbMole
Nat Commun. 2023 Mar 23;14(1):1606.
Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field
Ionomycin purchased from AbMole
Adv Sci (Weinh). 2023 Nov 30;e2305175.
Single‐Cell Atlas of Human Ovaries Reveals The Role Of The Pyroptotic Macrophage in Ovarian Aging
Ionomycin purchased from AbMole
J Immunother Cancer. 2023 Oct;11(10):e007230.
Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8+ T cell infiltration and functional transition
Ionomycin purchased from AbMole
Neurochem Res. 2023 Feb;48(2):447-457.
Ca2+ Regulates Autophagy Through CaMKKβ/AMPK/mTOR Signaling Pathway in Mechanical Spinal cord Injury: An in vitro Study
Ionomycin purchased from AbMole
Exp Cell Res. 2023 Nov 15;432(2):113778.
YTHDF1 shapes “cold” tumor and inhibits CD8+ T cells infiltration and function in breast cancer
Ionomycin purchased from AbMole
Hematol Oncol. 2023 Jul 26.
Magnesium enhances the graft-versus-tumor effect of donor lymphocytic infusion on hematologic malignancies
Ionomycin purchased from AbMole
Research Square. 2023 May 5.
Breast cancer intrinsic YTHDF1 forms “cold” tumor and inhibits CD8+ T cells infiltration and function
Ionomycin purchased from AbMole
Front Immunol. 2022 May 23;13:866638.
A Novel STAT3 Gain-of-Function Mutation in Fatal Infancy-Onset Interstitial Lung Disease
Ionomycin purchased from AbMole
| Molecular Weight | 709.01 |
| Formula | C41H72O9 |
| CAS Number | 56092-81-0 |
| Solubility (25°C) | Ethanol ≥ 10 mg/mL |
| Storage | -20°C, dry, protect from light, sealed |
| Related Calcium Channel Products |
|---|
| KB-R7943 mesylate
KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 mM). |
| Cilnidipine
Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. |
| Azelnidipine
Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Azelnidipine inhibits the intracellular calcium ion flow and lower blood pressure by selectively blocking L-type calcium channel on the membrane of vascular smooth muscle. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation by targeting MEK1/2. Azelnidipine also has anti-inflammatory, antioxidant and neuroprotective effects. |
| Catharanthine
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM |
| Cinepazide maleate
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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