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INY-03-041

Cat. No. M21434

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INY-03-041  Structure

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Quality Control & Documentation
Biological Activity

INY-03-041 is an effective and highly selective Protac-based pan-Akt degradation consisting of GDC-0068, an ATP-competitive AKT inhibitor conjugated to lenalidomide (Cereblon ligand). INY-03-041 inhibited AKT1, AKT2 and AKT3 with IC50 values of 2.0 nM, 6.8 nM and 3.5 nM, respectively.

Chemical Information
Molecular Weight 798.41
Formula C44H56ClN7O5
CAS Number 2503017-97-6
Solubility (25°C) DMSO : 115 mg/mL
Storage -20°C, dry, sealed
References

[1] Inchul You, et al. Cell Chem Biol. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

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  Catalog
Abmole Inhibitor Catalog




Keywords: INY-03-041 supplier, PROTAC, inhibitors, activators

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