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Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA.
| Molecular Weight | 348.44 |
| Formula | C21H24N4O |
| CAS Number | 125974-72-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 80 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
| Related Topoisomerase Products |
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| Dexrazoxane hydrochloride
Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. |
| Irinotecan Hydrochloride Trihydrate
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