All AbMole products are for research use only, cannot be used for human consumption.
Ingenol has been found to induce apoptosis and act as an anticancer agent. Ingenol derivatives have received constant and multidisciplinary attention on account of their pleiotropic pattern of biological activity.Ingenol is an activator of PKC ε and PKC δ.
| Molecular Weight | 348.40 |
| Formula | C20H28O5 |
| CAS Number | 30220-46-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Courtney E Heron, et al. Ingenol Mebutate and the Treatment of Actinic Keratosis
[2] No authors listed. Ingenol Mebutate
[3] Yasmin Khalfe, et al. Ingenol Mebutate: Expanded Utility
[5] Gillian M Keating. Ingenol mebutate gel 0.015% and 0.05%: in actinic keratosis
| Related PKC Products |
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Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively. |
| Go 6983
Go 6983 is a fast acting, lipid soluble, broad spectrum protein kinase C inhibitor. |
| Staurosporine
Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| Zoledronic acid
Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects. |
| Dequalinium Chloride
Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. |
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