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Inflexuside B

Cat. No. M21413

All AbMole products are for research use only, cannot be used for human consumption.

Inflexuside B Structure

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Quality Control & Documentation
Biological Activity

Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages

Chemical Information
Molecular Weight 644.75
Formula C35H48O11
CAS Number 1395048-86-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wei-Dong Xie, et al. Phytochemistry. Abietane diterpenoids from Isodon inflexus

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Imperatorin

Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM.

Crocin-II

Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA.

Madecassic-acid

Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages.

Irisflorentin

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Abmole Inhibitor Catalog




Keywords: Inflexuside B supplier, NO Synthase, inhibitors, activators

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