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INF39 is a nontoxic, irreversible NLRP3 inhibitor able to decrease interleukin-1β release from macrophages. INF39 (INF39) significantly inhibits ATP- and nigericin-induced IL-1β release. INF39 potentially reacts with Cys-SH residues in the active site of cysteine protease caspase-1, but does not directly target caspase-1 activity. The inhibition of NLRP3 inflammasome complex with INF39 dose-dependently attenuates the decrease in colonic length (-19, -13 and -8% at 12.5, 25, 50 mg/kg, respectively). Rats treated with INF39 displays a significant reduction of macroscopic damage score (4.7 at 12.5 mg/kg, 3.1 at 25 mg/kg, and 2.8 at 50 mg/kg). Oral administration of INF39 reduces colonic myeloperoxidase, IL-1β, and TNF Levels in DNBS-treated rats.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 224.68 |
| Formula | C12H13ClO2 |
| CAS Number | 866028-26-4 |
| Form | Liquid (density 1.131±0.06 g/mL) |
| Solubility (25°C) | DMSO 66 mg/mL |
| Storage | Pure form -20°C |
| Related NLR Products |
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| Nodinitib-1
Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. |
| Ruscogenin
Ruscogenin is an important steroid saponin extracted from Ophiopogon japonicum. It alleviates blood-brain barrier dysfunction induced by cerebral ischemia by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, and has significant anti-inflammatory and antithrombotic activities. |
| Procyanidin-B2
Procyanidin B2 is a natural flavonoid with anti-tumor and anti-oxidation effects. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. |
| Oridonin
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. |
| Shionone
Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. |
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