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Indomethacin farnesil

Cat. No. M30710

All AbMole products are for research use only, cannot be used for human consumption.

Indomethacin farnesil Structure
Synonym:

Indometacin farnesil

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Quality Control & Documentation
Biological Activity

Indomethacin farnesil is an orally active proagent of Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes.

Chemical Information
Molecular Weight 562.14
Formula C34H40ClNO4
CAS Number 85801-02-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] K Nomura, et al. Br J Dermatol. Angiolymphoid hyperplasia with eosinophilia: successful treatment with indomethacin farnesil

[2] T Arakawa, et al. Drugs Exp Clin Res. Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen

[3] S Kumakura, et al. Agents Actions. Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrageenin-induced inflammation in rats

[4] M Mishima, et al. Xenobiotica. Metabolic fate of indometacin farnesil, a prodrug of indomethacin: characteristic biotransformation of indometacin farnesil in rats

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Keywords: Indomethacin farnesil, Indometacin farnesil supplier, COX, inhibitors, activators

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