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Indisulam

Cat. No. M8477

All AbMole products are for research use only, cannot be used for human consumption.

Indisulam Structure
Synonym:

E 7070

Size Price Availability Quantity
1mg USD 35 In stock
5mg USD 75 In stock
10mg USD 110 In stock
25mg USD 180 In stock
50mg USD 275 In stock
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Quality Control & Documentation
Biological Activity

Indisulam is a carbonic anhydrase inibitor and antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.

Chemical Information
Molecular Weight 385.85
Formula C14H12ClN3O4S2
CAS Number 165668-41-7
Form Solid
Solubility (25°C) DMSO 50 mg/mL
Storage Powder -20°C
References

[1] Dirksen E Bussiere, et al. Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex

[2] Jiaqi Lu, et al. Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells

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Keywords: Indisulam, E 7070 supplier, PROTAC, inhibitors, activators

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