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Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor.
| Molecular Weight | 613.79 |
| Formula | C36H47N5O4 |
| CAS Number | 150378-17-9 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] R F Gagnon et al. Kidney Int. Indinavir crystalluria
[3] M Youle. HIV Med. Optimizing indinavir regimens
[4] D S Wu et al. Curr Opin Urol. Indinavir urolithiasis
[5] G L Plosker et al. Drugs. Indinavir: a review of its use in the management of HIV infection
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