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Indican

Cat. No. M30165

All AbMole products are for research use only, cannot be used for human consumption.

Indican Structure
Synonym:

Indoxyl-β-D-glucoside

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Quality Control & Documentation
Biological Activity

Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4.

Chemical Information
Molecular Weight 295.29
Formula C14H17NO6
CAS Number 487-60-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic) M;Ethanol 83.33 mg/mL (ultrasonic)
Water 20 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Yinghui Huang, et al. Theranostics. Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment

[2] Shiuan-Pey Lin, et al. J Food Drug Anal. Transporter-mediated interaction of indican and methotrexate in rats

[3] Souhaila Al Khodor, et al. Pediatr Nephrol. Gut microbiome and kidney disease: a bidirectional relationship

[4] Raymond Vanholder, et al. J Am Soc Nephrol. The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review

[5] J L Kirkland, et al. Postgrad Med J. Indican excretion in the elderly

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Keywords: Indican, Indoxyl-β-D-glucoside supplier, Fluorescent Dye, inhibitors, activators

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