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Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. Indapamide helps prevent your body from absorbing too much salt, which can cause fluid retention. Indapamide treats fluid retention (edema) in people with congestive heart failure.
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Source | J Pharmacol Exp Ther (2008). Figure 5. Indapamide |
| Method | BM-MNC Differentiation into EPCs. | |
| Cell Lines | normotensive Wistar Kyoto (WKY) rats | |
| Concentrations | 10 μM | |
| Incubation Time | 7 d | |
| Results | It is noteworthy that treatment with perindopril, indapamide, or both increased the number of cells double positive for both AcDil-LDL and BS-1 lectin by 1.7-, 1.4-, and 2.0-fold, (p 0.01), respectively, in ischemic SHRs in reference to untreated ischemic SHRs |
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Source | J Pharmacol Exp Ther (2008). Figure 3. Indapamide |
| Method | Western Blot | |
| Cell Lines | normotensive Wistar Kyoto (WKY) rats | |
| Concentrations | 10 μM | |
| Incubation Time | 7 d | |
| Results | It is interesting to note that coadministration of perindopril and indapamide markedly increased VEGF protein expression in ischemic SHRs in reference to untreated ischemic SHRs |
| Cell Experiment | |
|---|---|
| Cell lines | Rat A10 vascular smooth muscle cells |
| Preparation method | The cultures were then incubated in DMEM with 10% foetal calf serum, containing vehicle alone or various concentrations of indapamide Ž10y6 ,10y5, 5=10y5 and 5=10y4 . for 16 h, then for 2 h in the same medium containing BrdU Ž10y5 M.. |
| Concentrations | 1, 10, 50, 500 μM |
| Incubation time | 16 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 365.83 |
| Formula | C16H16ClN3O3S |
| CAS Number | 26807-65-8 |
| Solubility (25°C) | DMSO 63 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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