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INCB 3284 dimesylate exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). INCB 3284 also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μM).
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | male C57Bl/6 mice |
| Formulation | |
| Dosages | 1 mg/kg/day |
| Administration | i.p. |
| Molecular Weight | 712.76 |
| Formula | C28H39F3N4O10S2 |
| CAS Number | 887401-93-6 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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