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Inauhzin is a novel small molecule that reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell) effectively By increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, INZ stabilizes p53,though not directly in vitro. Remarkably, INZ inhibits cell proliferation, induces senescence and tumour-specific apoptosis.
| Molecular Weight | 469.58 |
| Formula | C25H19N5OS2 |
| CAS Number | 309271-94-1 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related p53 Products |
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