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Imeglimin hydrochloride (EMD 387008) is a first-in-class, oral glucose-lowering agent. Imeglimin reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.
Imeglimin (200 mg/kg; b.i.d.; oral gavage during the last 6 weeks of HFHSD feeding) treatment in Male C57BL/6JOlaHsd mice (4 weeks old) significantly decreases hyperglycemia, and restores normal glucose tolerance.
| Molecular Weight | 191.66 |
| Formula | C6H14ClN5 |
| CAS Number | 775351-61-6 |
| Solubility (25°C) | Water 45 mg/mL DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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