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IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway. IMD-0354 inhibits NF-κB activity in HMC-1 cells, resulting in complete repression of growth factor-independent proliferation of mast cells. When the DNA-binding activity of NF-κB is inhibited by treatment with IMD-0354, cell proliferation is completely suppressed. HMC-1 cells are incubated with increasing concentrations of IMD-0354 or STI571 for 24, 48, and 72 hours, and numbers and viability of cells are determined by a dye exclusion test and an MTT assay. IMD-0354 suppresses cell proliferation in a time- and dose-dependent manner. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2±0.3 uM.
J Ethnopharmacol. 2024 Apr 20.
Network pharmacology-based research into the mechanism of ferulic acid on acute lung injury through enhancing transepithelial sodium transport
IMD 0354 purchased from AbMole
Journal of Third Military Medical University. 2016;36(15): 1735-1740.
Role of calcitriol on epithelial-mesenchymal transition of NRK52E cells induced by advanced glycation end products
IMD 0354 purchased from AbMole
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Source | Redox Biol (2018). Figure 4. IMD 0354 |
| Method | inject | |
| Cell Lines | mice | |
| Concentrations | 30 mg/kg/d | |
| Incubation Time | 3 weeks | |
| Results | Notably, administration of IMD-0354 to rAAV2-LMP10-injected mice significantly blocked Ang II-induced increases in the central retinal thickness, vascular permeability and VEGF expression at both mRNA and protein levels compared with vehicle control. |
| Molecular Weight | 383.67 |
| Formula | C15H8ClF6NO2 |
| CAS Number | 978-62-1 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IκB/IKK Products |
|---|
| BAY 11-7082
BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| SC-514
SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM. |
| TPCA-1
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| BMS-345541 hydrochloride
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively). BMS-345541 binds at an allosteric site of IKK. |
| Bardoxolone Methyl
Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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