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Protein Kinase C (PKC) inhibitor; an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. IC50 = 560 nM. Competitive at the regulatory site of PKC. Ilmofosine is active against a variety of explanted human non-small cell lung, breast, colorectal, ovarian, renal cell cancer, and melanoma tumors in vitro at concentrations of 1-30 μg/mL.
| Molecular Weight | 525.77 |
| Formula | C26H56NO5PS |
| CAS Number | 83519-04-4 |
| Solubility (25°C) | Water: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Samira Azzouz, et al. Leishmanicidal activity of edelfosine, miltefosine and ilmofosine
[3] J Hofmann, et al. Resistance to the new anti-cancer phospholipid ilmofosine (BM 41 440)
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