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IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
| Cell Experiment | |
|---|---|
| Cell lines | NSCLC cell lines |
| Preparation method | Similar results were obtained at the levels of IKKγ, IKBα, and p65 phosphorylation, which were downregulated in ANXA1-overexpressed cells with IKK-16 (100 nM) inhibitor treatment, miR-26a was found to be elevated under this condition. |
| Concentrations | 100 nM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Wistar rat |
| Formulation | - |
| Dosages | 1 mg/kg |
| Administration | Tail vein injections |
| Molecular Weight | 483.63 |
| Formula | C28H29N5OS |
| CAS Number | 873225-46-8 |
| Solubility (25°C) | DMSO 67 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Eric Dietel, et al. PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells
| Related IκB/IKK Products |
|---|
| BAY 11-7082
BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| SC-514
SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) with IC50 of 3-12 μM. |
| TPCA-1
TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM. |
| BMS-345541 hydrochloride
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IC50 values of 0.3 μM and 4 μM for IKK-2 and IKK-1 respectively). BMS-345541 binds at an allosteric site of IKK. |
| Bardoxolone Methyl
Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. |
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