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IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir improves the antiviral efficacy.
| Molecular Weight | 443.62 |
| Formula | C23H45N3O5 |
| CAS Number | 1447464-73-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Glucosidase Products |
|---|
| Acarbose
Acarbose (BAY G 5421) is an alpha-glucosidase inhibitor with oral activity (IC50=11 nM). Acarbose can enhance the hypoglycemic effect of sulfonylurea inhibitors or insulin. |
| Voglibose
Voglibose is an N-substituted derivative of valiolamine, excellent inhibitory activity against α-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia. |
| 1-Deoxynojirimycin
1-deoxynojirimycin (Duvoglustat) is an oral effective α-glucosidase inhibitor. 1-Deoxynojirimycin inhibits postprandial blood glucose and prevents diabetes. 1-Deoxynojirimycin has hypoglycemic, weight loss and antiviral effects. |
| Licochalcone-C
Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. Licochalcone-C is an inhibitor of lipopolysaccharide-interferon-γ inflammation. |
| Rebaudioside-A
Rebaudioside A is A steviol glycoside, α-glucosidase inhibitor, IC50 is 35.01ug /mL. |
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