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Recombinant Human IFN-β (E. coli, C-His)

Cat. No. M13441

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human IFN-β (E. coli, C-His) Structure
Synonym:

Interferon-Beta

Size Price Availability Quantity
5ug USD 110 In stock
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Quality Control & Documentation
  • Purity: >98%, Endotoxin < 0.1 EU/μg
  • COA
  • MSDS
Biological Activity

Interferon β (IFN-β) acts via STAT1 and STAT2 and is known to up-regulate and down-regulate a variety of genes, most of which are involved in antiviral immune responses. It is a member of type I interferon, which includes IFN-α, -β, τ and -ω. IFN-β plays an important role in inducing nonspecific resistance to a wide range of viral infections. It also affects cell proliferation and modulates immune responses.

Recombinant Human Interferon beta expressed the target gene encoding Met22-Asn187 with polyhistidine tag at the C-terminus.

Measure by its ability to induce cytotoxicity in TF-1 cells, the ED50 for this effect is <0.1 ng/mL. The specific activity is approximately >1x107 IU/mg.


Accession: P01574

Apparent Molecular Weight: 15 KDa, under reducing conditions

Endotoxin < 0.1 EU/µg

Lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Zhang Xiangbo, et al. Arch Microbiol. Bovine coronavirus nucleocapsid suppresses IFN-β production by inhibiting RIG-I-like receptors pathway in host cells

[2] Samira Khiar, et al. Sci Rep. Identification of a small molecule that primes the type I interferon response to cytosolic DNA

[3] Kay-Sara Sauter, et al. Vet Immunol Immunopathol. Stable transduction of bovine TLR4 and bovine MD-2 into LPS-nonresponsive cells and soluble CD14 promote the ability to respond to LPS

[4] Meenakshi Upreti, et al. Biochem Biophys Res Commun. Replacement of 198MQMDII203 of mouse IRF-1 by 197IPVEVV202 of human IRF-1 abrogates induction of IFN-beta, iNOS, and COX-2 gene expression by IRF-1

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Keywords: Recombinant Human IFN-β (E. coli, C-His), Interferon-Beta supplier, Cytokines and Growth Factors, inhibitors, activators

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