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IDO1/TDO-IN-4 is a potent dual IDO1/TDO inhibitor with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bonds with IDO1 and interacts with TDO in π-π stacking. IDO1/TDO-IN-4 can be used in the study of depression, as well as depression-induced infectious, metabolic and autoimmune diseases.
| Molecular Weight | 234.26 |
| Formula | C14H10N4 |
| CAS Number | 461424-21-5 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Lijie Zhai, et al. Cell Mol Immunol. IDO1 in cancer: a Gemini of immune checkpoints
| Related IDO Products |
|---|
| IDO-IN-2 (NLG-919 Analogue)
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. |
| IDO5L
IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM. |
| Coptisine
Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. |
| Coptisine chloride
Coptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection. |
| Coptisine-Sulfate
Coptisine Sulfate is an alkaloid isolated from coptis coptidis. It is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. |
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Products are for research use only. Not for human use. We do not sell to patients.
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