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ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.
| Molecular Weight | 207.23 |
| Formula | C9H13N5O |
| CAS Number | 27277-00-5 |
| Solubility (25°C) | DMSO 20.72 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Seitzberg, et al. J Med Chem. Discovery of potent and selective small-molecule PAR-2 agonists.
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