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ICI 192605

Cat. No. M7855

All AbMole products are for research use only, cannot be used for human consumption.

ICI 192605 Structure

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Quality Control & Documentation
Biological Activity

ICI 192605 is a potent thromboxane A2 receptor antagonist. It inhibits platelet aggregation and can reverse the effects of vasoconstrictors such as TXA2 or PGD2. ICI 192605 can reverse vasoconstriction induced by inhibition of NO production by L-NEMA, which leads to an increase in TXA2 release.

Chemical Information
Molecular Weight 402.87
Formula C22H23ClO5
CAS Number 117621-64-4
Solubility (25°C) DMSO: ≥20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Matthew M Hewitt, et al. Pharmacology of Bradykinin-Evoked Coughing in Guinea Pigs

[2] Luke J Janssen, et al. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature

[3] N al Jarad, et al. Effects of a thromboxane receptor antagonist on prostaglandin D2 and histamine induced bronchoconstriction in man

[4] A G Brewster, et al. The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid ICI 192605

[5] G R Brown, et al. Improved synthetic routes to the novel thromboxane receptor antagonist ICI 192605: activity of synthetic 1,3-dioxane intermediates

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Keywords: ICI 192605 supplier, inhibitors, activators

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