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ICI 118,551 hydrochloride is a highly selective β2-adrenoceptor antagonist, with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.
J Ethnopharmacol. 2025 Feb 17;26:344:119517.
Paeoniflorin inhibits chronic restraint stress-induced progression of hepatocellular carcinoma through suppressing norepinephrine-induced activation of hepatic stellate cells via SRC/AKT/ERK pathways
ICI 118,551 hydrochloride purchased from AbMole
| Molecular Weight | 313.86 |
| Formula | C17H27NO2.HCl |
| CAS Number | 72795-01-8 |
| Solubility (25°C) | Water 8 mg/mL DMSO 30 mg/mL |
| Storage | 4°C, dry, sealed |
[5] O E Brodde. The functional importance of beta 1 and beta 2 adrenoceptors in the human heart
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