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ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds to the N-terminal domain of TRADD (TRADD-N), breaking its binding to TRADD-C and TRAF2. ICCB-19 hydrochloride is an indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and degradation of long-lived proteins.
| Molecular Weight | 291.84 |
| Formula | C12H22ClN3OS |
| CAS Number | 1803605-68-6 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | 4°C protect from light dry |
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