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Icatibant (HOE-140) acetate is a potent and specific peptide antagonist of bradykinin B2 receptor, with IC50 value of 1.07 nM and Ki value of 0.798 nM, respectively. Icatibant (0.3 or 1.5 mg/kg; subcutaneous administration twice daily) in mice shows a significant preventive effect on ulcerative Colitis.
| Molecular Weight | 1364.57 |
| Formula | C61H93N19O15S |
| CAS Number | 138614-30-9 |
| Form | Solid |
| Solubility (25°C) | Water 45 mg/mL |
| Storage | -20°C, sealed, protect from light |
| Related Bradykinin Receptor Products |
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| ELN 441958
ELN-441958 is a potent, neutral, competitive and selective oral bioavailable bradykinin B1 receptor antagonist with a Ki of 0.26 nM against native human bradykinin B1 receptor. |
| SSR240612
Treatment with the kinin B1 receptor antagonist, SSR240612, provided a protective effect against organ damage by interfering with multiple target functions, including the suppression of B1R-induced inflammation and platelet aggregation. |
| Bradykinin
Bradykinin (bradykinin) is a vasodilator active peptide produced by the kinin-releasing enzyme-kinin system that modulates inflammation by causing vasodilation, increasing vascular permeability, and stimulating prostaglandin synthesis. |
| Icatibant
Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. |
| [Des-Arg9]-Bradykinin
[Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors. |
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