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IBR2

Cat. No. M13725

All AbMole products are for research use only, cannot be used for human consumption.

IBR2 Structure
Size Price Availability Quantity
10mg USD 140 In stock
25mg USD 230 In stock
50mg USD 330 In stock
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Biological Activity

IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis.

Chemical Information
Molecular Weight 400.49
CAS Number 313526-24-8
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] J A Gibbard, et al. J Chem Phys. Photoelectron-photofragment coincidence spectroscopy of the mixed trihalides

[2] Peter J Ferguson, et al. J Pharmacol Exp Ther. Synergistic Antiproliferative Activity of the RAD51 Inhibitor IBR2 with Inhibitors of Receptor Tyrosine Kinases and Microtubule Protein

[3] Jiewen Zhu, et al. EMBO Mol Med. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia

[4] Xiao-Long Qiu, et al. J Org Chem. Stereoselective synthesis of chiral IBR2 analogues

[5] M C Aragoni, et al. Chemistry. Mechanistic aspects of the reaction between Br2 and chalcogenone donors (LE; E=S, Se): competitive formation of 10-E-3, T-shaped 1:1 molecular adducts, charge-transfer adducts, and [ (LE)2]2+ dications

Related RAD51 Products
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CAM833

CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization.

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Abmole Inhibitor Catalog




Keywords: IBR2 supplier, RAD51, inhibitors, activators

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