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Ianalumab (VAY-736) is a humanized, decarboxylated antibody against BAFF-R. Ianalumab can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM).
| CAS Number | 1929549-92-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Albert J Czaja. Dig Dis Sci. Advancing Biologic Therapy for Refractory Autoimmune Hepatitis
[3] Clio P Mavragani, et al. J Autoimmun. Sjögren's syndrome: Old and new therapeutic targets
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