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Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonist.
| Molecular Weight | 255.74 |
| Formula | C13H18ClNO2 |
| CAS Number | 92264-81-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] T E Schwasinger-Schmidt, et al. Handb Exp Pharmacol. Other Antidepressants
[2] Jian Li, et al. J Labelled Comp Radiopharm. Synthesis of deuterium-labeled hydroxybupropion
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