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Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Huwentoxin-IV TFA inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
| Molecular Weight | 4220.80 |
| Formula | C176H279F3N52O53S6 |
| CAS Number | 526224-73-7 (free base) |
| Solubility (25°C) | Water 1 mg/mL |
| Storage | -20°C, sealed |
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