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HS271 is an orally potent and selective IRAK4 inhibitor with an IC50 value of 7.2 μM. In addition, HS271 has superior in vitro enzymatic and cellular activities.
| Molecular Weight | 435.44 |
| Formula | C21H24F3N5O2 |
| CAS Number | 2410393-15-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IRAK Products |
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CA-4948 is a selective, potent and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) that regulates IRAK4 function in the TLR and IL-1R signaling cascades. CA-4948 has good pharmacokinetic characteristics and antitumor activity in vitro and in vivo. |
| AS 2444697
AS 2444697 is a potent and selective IRAK4 inhibitor. |
| Zimlovisertib
PF06650833 (Zimlovisertib) is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). |
| IRAK-1-4 Inhibitor I
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| Zabedosertib
Zabedosertib (BAY 1834845) is a selective, orally potent IRAK4 inhibitor with immunomodulatory and anti-inflammatory activity and an IC50 value of 3.55 nM. Zabedosertib (BAY 1834845) exhibits anti-inflammatory property against IL-β, LPS and Imiquimod induced inflammation. |
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